EFFECT OF TONGKAT ALI ON STRESS HORMONES AND PSYCHOLOGICAL MOOD STATE IN MODERATELY STRESSED SUBJECTS

EFFECT OF TONGKAT ALI ON STRESS HORMONES AND PSYCHOLOGICAL MOOD STATE IN MODERATELY STRESSED SUBJECTS

  JUN 14, 2023   NEWS  VIEWS (1)

Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects

BACKGROUND

Eurycoma longifolia is a medicinal plant commonly called tongkat ali (TA) and “Malaysian ginseng.” TA roots are a traditional “anti-aging” remedy and modern supplements are intended to improve libido, energy, sports performance and weight loss. Previous studies have shown properly-standardized TA to stimulate release of free testosterone, improve sex drive, reduce fatigue, and improve well-being.

METHODS

We assessed stress hormones and mood state in 63 subjects (32 men and 31 women) screened for moderate stress and supplemented with a standardized hot-water extract of TA root (TA) or Placebo (PL) for 4 weeks. Analysis of variance (ANOVA) with significance set at p < 0.05 was used to determine differences between groups.

RESULTS

Significant improvements were found in the TA group for Tension (−11%), Anger (−12%), and Confusion (−15%). Stress hormone profile (salivary cortisol and testosterone) was significantly improved by TA supplementation, with reduced cortisol exposure (−16%) and increased testosterone status (+37%).

CONCLUSION

These results indicate that daily supplementation with tongkat ali root extract improves stress hormone profile and certain mood state parameters, suggesting that this “ancient” remedy may be an effective approach to shielding the body from the detrimental effects of “modern” chronic stress, which may include general day-to-day stress, as well as the stress of dieting, sleep deprivation, and exercise training.

Keywords: Testosterone, Cortisol, Stress, Vigor, Tongkat ali, Eurycoma, Mood

BACKGROUND

Eurycoma longifolia is an herbal medicinal plant found in South East Asia (Malaysia, Vietnam, Java, Sumatra, Thailand). In Malaysia, it is commonly called tongkat ali and has a range of medicinal properties as a general health tonic, including improvement in physical and mental energy levels and overall quality of life [1,2]. The roots of tongkat ali, often called “Malaysian ginseng”, are used as an adaptogen and as a traditional “anti-aging” remedy to help older individuals adapt to the reduced energy, mood, and libido that often comes with age [3-7]. In modern dietary supplements, tongkat ali can be found in a variety of products intended to improve libido and energy, restore hormonal balance (cortisol/testosterone levels) and enhance both sports performance and weight loss. The objective of this study was to evaluate the effects of tongkat ali extract on stress hormone balance (cortisol/testosterone) and psychological mood state in moderately stressed subjects.

In both men and women, testosterone levels peak between 25 to 30 years of age - and thereafter drop approximately 1-2% annually [8,9]. At the age of 60, testosterone levels are typically only 40-50% of youthful levels and may be lower due to stress and related lifestyle issues such as diet, exercise, and sleep patterns [10,11]. The benefits of maintaining a youthful testosterone levels are many, including increased muscle mass and reduced body fat, high psychological vigor (mental/physical energy), and improved general well-being [12,13].

Eurycoma contains a group of small peptides referred to as “eurypeptides” that are known to have effects in improving energy status and sex drive in studies of rodents [14-16]. The effects of tongkat ali in restoring normal testosterone levels appears to be less due to actually “stimulating” testosterone synthesis, but rather by increasing the release rate of “free” testosterone from its binding hormone, sex-hormone-binding-globulin (SHBG) [17,18]. In this way, eurycoma may be considered not so much a testosterone “booster” (such as an anabolic steroid), but rather a “maintainer” of normal testosterone levels and a “restorer” of normal testosterone levels (from “low” back “up” to normal ranges) [19]. This would make eurycoma particularly beneficial for individuals with sub-normal testosterone levels, including those who are dieting for weight loss, middle-aged individuals suffering with fatigue or depression, and intensely training athletes who may be at risk for overtraining [20,21].

Figure 1

Profile of Mood States (POMS). Daily supplementation (200 mg/day for 4 weeks) with tongkat ali (TA) resulted in significant improvements compared to placebo (PL) for indices of Tension (−11%), Anger (−12%), and Confusion (−15%) in moderately stressed adults (N = 63). * = p < 0.05 by ANOVA.

Hormone profile (salivary cortisol and testosterone) was significantly improved by TA supplementation, with reduced cortisol exposure (−16%, Figure 2), increased testosterone status (+37%, Figure 3) and overall improved cortisol:testosterone ratio (−36%) in the TA group compared to placebo.

Figure 2

Salivary cortisol. Salivary cortisol levels were significantly lower (−16% compared to placebo, PL) following tongkat ali (TA) supplementation (200 mg/day for 4 weeks). * = p < 0.05 by ANOVA.

Figure 3

Salivary testosterone. Salivary testosterone levels were significantly higher (+37% compared to placebo, PL) following tongkat ali (TA) supplementation (200 mg/day for 4 weeks). * = p < 0.05 by ANOVA.